Anti-Glycation Really Delay Skin Aging

Update:2023-07-03   

  Glycation of the skin refers to the phenomenon where sugars and proteins within our body combine, causing protein degeneration and resulting in a yellowing and brittle appearance. To put it simply, it is like a rusty spring losing its elasticity. Glycation actually causes significant damage to the skin, leading to dullness and loss of elasticity.

  Extensive research has shown that the byproducts of the glycation process, known as AGEs, can impact the functionality of collagen in the skin and indeed contribute to skin aging.

What is "glycation" and how is it related to aging?

  The term "glycation" was coined in 1912 when it was initially discovered by French chemist Maillard. At that time, it was not associated with "aging" but was used to describe the browning reaction that occurs during food heating, known as the Maillard reaction.

  However, further research has found that glycation also occurs in human bodies and is involved in the development of various diseases, such as complications of diabetes. In recent years, it has also been found to be associated with skin aging.

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What are the effects of glycation on the skin? 

After glycation, collagen and elastin proteins will not be able to function properly, leading to gradual skin sagging. In addition, glycation in the dermis can cause the skin to gradually become yellow, while glycation in the stratum corneum can reduce the skin's moisture retention function, resulting in dryness and roughness.

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To some extent, "glycation" indeed acts as an accomplice to the loss of collagen! In addition, AGEs can slow down the renewal speed of epidermal keratinocytes, increase cellular apoptosis, and hinder the timely metabolism of old keratinocytes, resulting in dull and rough-looking skin.

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Another point to consider is that AGEs also inhibit the body's natural antioxidant enzymes, making it more susceptible to sun damage and resulting in photoaging, which is one of the main causes of skin aging.

▍ Sun Exposure

Studies have found that AGEs levels are not high in the skin that has not been exposed to or has had minimal sun exposure, regardless of age. However, there is a significant increase in the accumulation of AGEs in the skin that has been exposed to sunlight.

Research shows that the accumulation of advanced glycation end products (AGEs) is significantly lower in areas that are less likely to be exposed to sunlight, such as the abdomen, chest, and back, compared to parts of the body that are exposed to sunlight, such as the nose and forehead.

From the perspective of "anti-glycation," sunscreen is still of great importance.