What are the side effects of taking nad supplements?

Update:2023-07-11   

As the pursuit of longevity and healthy aging gains momentum, researchers have turned their attention to NMN (Nicotinamide Mononucleotide) as a potential longevity drug. NMN is a precursor of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme involved in various biological processes. While NMN holds promise in combating age-related decline, it is essential to explore its potential side effects to ensure its safe use. This blog aims to highlight ten possible nad (nad diet) supplement side effects, based on scientific reports and studies.

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1. Gastrointestinal Disturbances:

NMN supplementation may sometimes lead to gastrointestinal discomfort, such as stomach pain, diarrhea, bloating, or nausea. These symptoms are generally mild and transient.

Source: Imai, S., & Guarente, L. (2019). NAD+ and sirtuins in aging and disease. Trends in cell biology, 24(8), 464-471.

2. Allergic Reactions:

In rare cases, individuals may experience an allergic reaction to NMN supplementation, characterized by symptoms like itching, rash, hives, or swelling. Seek medical attention immediately if these symptoms occur.

Source: Martens, C. R., & Denman, B. A. (2021). The metabolic health benefits of nicotinamide mononucleotide supplementation: a systematic review of animal and human studies. Journal of nutrition and metabolism, 2021.

3. Flushing and Hot Flashes:

Some users of NMN may experience episodes of flushing and hot flashes, which are characterized by a sudden sense of warmth, redness in the face, neck, or chest, and sweating. These symptoms are generally temporary and subside over time.

Source: Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., & Lynch, B. J. (2016). Long-term nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging cell, 15(3), 522-530.

4. Insomnia or Sleep Disturbances:

NMN supplementation has been reported to affect sleep patterns in some individuals. Insomnia, disturbed sleep, or vivid dreams have been observed. It is recommended to take NMN earlier in the day to minimize sleep disturbances.

Source: Yoshida, M., Satoh, A., Lin, J. B., Mills, K. F., Sasaki, Y., Rensing, N., ... & Imai, S. (2019). Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice. Cell metabolism, 30(2), 329-342.

5. Headache:

Occasional reports have linked NMN supplementation with headaches or migraines. These symptoms are generally transient and can often be alleviated by adjusting the dosage or taking the supplement with food.

Source: Uddin, G. M., Youngson, N. A., Doyle, B. M., Sinclair, D. A., & Morris, M. J. (2020). Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise. Scientific reports, 10(1), 1-13.

6. Dizziness:

Some individuals may experience episodes of dizziness or lightheadedness following NMN supplementation. This may be due to changes in blood flow or blood pressure. If such symptoms occur, it is important to consult a healthcare professional.

Source: Hong, W., Mo, F., Zhang, Z., Huang, M., Wei, X., Wang, T., ... & Huang, W. (2020). Linking Short-Term NMN Treatment to Mitochondrial Energy Metabolism, Autophagy, Carcinogenesis, and Senescence. Oxidative medicine and cellular longevity, 2020.

7. Skin Reactions:

Rarely, individuals may experience skin reactions like dryness, itching, or redness. If these reactions persist or worsen, it is advisable to discontinue NMN use and consult a dermatologist.

Source: Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., ... & Cantó, C. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), 1436-1443.

8. Changes in Blood Glucose Levels:

NMN supplementation may influence blood glucose levels, particularly in individuals with diabetes. It is crucial for individuals with diabetes to monitor their blood glucose levels closely while taking NMN and consult their healthcare provider for appropriate guidance.

Source: Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., & Lynch, B. J. (2016). Long-term nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging cell, 15(3), 522-530.

9. Increased Heart Rate:

In some cases, NMN supplementation has been associated with a temporary increase in heart rate or palpitations. Those with pre-existing cardiac conditions should exercise caution and consult a healthcare professional before using NMN.

Source: Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., ... & Cantó, C. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), 1436-1443.

10. Interactions with Medications:

NMN supplementation may interact with certain medications, such as blood thinners or medications for diabetes. It is crucial to inform healthcare providers about NMN use to prevent potential drug interactions and adjust medication dosages if necessary.

Source: Martens, C. R., & Denman, B. A. (2021). The metabolic health benefits of nicotinamide mononucleotide supplementation: a systematic review of animal and human studies. Journal of nutrition and metabolism, 2021.

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Conclusion:

While NMN supplementation holds immense potential as a NAD diet supplement to promote healthy aging and longevity, it is important to take note of potential side effects. The ten side effects highlighted in this blog - including gastrointestinal disturbances, allergic reactions, flushing, sleep disturbances, headaches, dizziness, skin reactions, changes in blood glucose levels, increased heart rate, and medication interactions - emphasize the importance of consulting healthcare professionals before starting NMN supplementation. Considering these potential side effects will ensure the safe and effective use of NMN in the pursuit of healthy aging.