NMN Still Leading the Way in 2023

Update:2023-08-04   

nmnsupplier.com's CEO Mr Xi

In 2023, NMN is expected to continue dominating the market as a leading health supplement. As China enters an aging society, the challenges of chronic diseases, functional decline, and overall health issues, particularly immune deficiencies, will become more prevalent. One of the missions of the nutrition and health industry is to strengthen the foundation of basic health as the first line of defense.

NMN and probiotics can be regarded as the "double top players" of functional ingredients, generating significant attention in various related topics.

Let's take a look at the hottest topics surrounding NMN in the past year!

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Research Progress

NMN is not only a hot topic in the industry but also at the forefront of research. In 2022, there was a significant increase in global research related to NMN, with 166 publications found in the PubMed database alone, indicating an exponential growth trend.

Furthermore, there were 2,236 studies related to NAD+ published in the same year.

Throughout 2022, nmnsupplier.com observed numerous domestic and international universities and renowned institutions conducting research on NMN and NAD+. The articles focused on the efficacy of NMN/NAD+ in anti-aging, DNA repair, diabetes, exercise and weight loss, neurological cognition, cardiovascular health, liver protection, vision and hearing protection. Recent studies have also discovered its remarkable antiviral abilities. Two of the most popular studies were:

"Chinese Academy of Sciences Discovers NMN's Contribution to the Prevention and Treatment of COVID-19": On April 29, 2022, a research article titled "Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models" was published in the journal Cell Discovery by a team led by Xu Zhiheng from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, in collaboration with Qin Chengfeng from the Beijing Institute of Microbiology and Epidemiology and Hu Zeping from the School of Pharmaceutical Sciences of Tsinghua University. The study found that supplementing NMN had similar effects to NAD+ in improving NAD+ metabolism, immune response, and gene expression related to cell death, thereby inhibiting cell death caused by COVID-19. This discovery sparked significant market movement after being reported domestically, with companies such as Jindawei, Anqi Yeast, and Xiwang Food also experiencing stock price increases.

"Significant Findings in NAD+ and Aging Research": On March 21, 2022, a research article titled "Association of Human Whole Blood NAD+ Contents With Aging" was published in the prestigious journal Frontiers in Endocrinology, jointly led by the Clinical Research Institute of the First Affiliated Hospital of Shanghai Jiao Tong University School of Medicine, Jinan University, and the Tongcheng Group Healthy Nutrition Research Institute. The study explored the relationship between blood NAD+ levels and aging, showing significant gender differences, particularly in middle-aged and elderly men. This large-scale study included 1,518 Chinese participants aged 18 and above recruited between 2019 and 2020, making the results highly relevant to the local population.

In addition to these studies, there were also notable clinical research findings in 2022. For instance:

In June, a team of Japanese scientists conducted a clinical trial that confirmed the role of NMN in improving glucose and lipid metabolism, as well as enhancing immune system regulation. (DOI: 10.24659/gsr.9.2_33)

In September, researchers from Hyogo College of Medicine in Japan discovered through human clinical trials that intravenous administration of NMN not only increased NAD+ levels significantly but also significantly reduced triglyceride levels, showing reliable safety. (DOI: 10.7759/cureus.28812)

Global Regulatory Progress

While NMN is a highly enticing nutritional supplement, it is not yet approved for production and distribution as a food or drug in China. Currently, it can only be sold to China through cross-border e-commerce platforms.

Therefore, industry leaders are closely following the compliance progress of NMN on a global scale. As of December 31, 2022, the regulatory developments of NMN in major countries worldwide were as follows:

In 2022, the following compliance topics gained significant attention:

"State Administration for Market Regulation: Suggestion to Evaluate NMN as a New Food Ingredient": In early 2022, four companies successfully applied for NMN as a new ingredient in cosmetic products, bringing much hope to the industry. In response to proposals at the two sessions (the National People's Congress and the Chinese People's Political Consultative Conference), the State Administration for Market Regulation stated that the positioning and safety of NMN as a food ingredient were still unclear, lacking national food safety standards. They suggested conducting safety assessments in accordance with the new food ingredient evaluation process or clarifying national food safety standards. The administration pointed out that NMN and related products were not registered as health supplements in China, and the conditions for NMN to be used as an ingredient in health supplements were not yet mature, necessitating further monitoring and research. The State Administration for Market Regulation, along with other relevant departments such as the National Health Commission and the National Medical Products Administration, will support basic research on NMN and related products, guiding their standardized development.

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