Andrew huberman’s view aboutNAD+ precursors NMN and NR (w/ Rogan)


NAD (nicotinamide adenine dinucleotide) is crucial for cellular health and energy production but tends to decrease with age. Researchers have been studying the potential of stimulating NAD pathways, using compounds such as NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside), to extend lifespan. NMN and NR can be taken in oral form as capsules, and some people also opt for NAD infusions. There is controversy over which compound is better, with arguments for both NMN and NR. Dr. Andrew Huberman has personally experimented with both NMN and NR, finding an increase in energy with NMN. Sublingual administration (under the tongue) of NMN is believed to be more effective than taking it in pill form. However, there have been recent regulatory concerns regarding NMN. The FDA has ruled that supplement companies cannot market NMN, potentially leading to it becoming a prescription drug. The company Metro International Biotech is studying a variation on NMN that has the potential to become a prescription drug. Dr. Huberman suggests that writing letters to the FDA in support of keeping NMN as a supplement may help maintain its availability. NR companies, on the other hand, are pleased with the situation and hopeful that the controversy surrounding NMN will result in increased recognition for NR. Dr. Huberman recommends refrigeration for NR supplements. His personal experience with NMN suggests benefits such as improved energy, workout recovery, and accelerated hair and nail growth, but further research is needed to determine its potential impact on lifespan.